Synthesis of Polycaprolactone-Hydroxyapatite (PCL-HA) Biodegradable Nanofibres Via an Electrospinning Technique for Tissue Engineering Scaffolds

نویسندگان

چکیده

The interest in biodegradable polymer nanofibres with tissue cell regeneration potential has increased recent years. However, there are issues the development of scaffolding to provide a favourable environment for proliferation and attachment. Such can be overcome by addition hydroxyapatite (HA), which is widely used biomaterial applications. Biodegradable polycaprolactone (PCL) (HA) have been produced electrospinning. In this study, PCL was mixed HA synthesise single nozzle Furthermore, PCL-HA were fibronectin investigate effect adhesion surface nanofibres. structure morphology determined scanning electron microscopy (SEM), chemical properties analysed Fourier transform infrared (FTIR), diameter adhesive force nanofibers an atomic microscope (AFM). SEM examination revealed formation cylindrical smooth dense fibre networks when 10% used, as generate fibre. FTIR analysis indicated presence inside AFM showed that 100 µg/ml gives highest important scaffold resist from external environment. This outcome resulted indicates promising engineering application. Hence, further investigations needed ensure compatibility living cells survive grow on nanofibrous mats.

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ژورنال

عنوان ژورنال: Jurnal Kejuruteraan

سال: 2021

ISSN: ['2289-7526', '0128-0198']

DOI: https://doi.org/10.17576/jkukm-2021-33(4)-16